Trazodone Impurity 91 CAS 53818-10-3 (free base)
| CAS No. | 53818-10-3 (free base) |
| Molecular Formula | C19H22ClN5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Trazodone Impurity 91 (CAS 53818-10-3 (free base)), a pharmacopoeial impurity reference standard (molecular formula C19H22ClN5O2HCl, MW 424.33 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Trazodone Impurity 91 (C19H22ClN5O2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Trazodone Impurity 91 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H22ClN5O2 HCl |
| Molecular Weight | 424.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Trazodone Standards
- Trazodone Impurity N13 (CAS 101364-27-6)
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
Recommended Standards
- Linagliptin Impurity 13 (CAS 2742623-47-6)
- Levosimendan Impurity 24 (CAS CATO-C4X-130824)
- Olaparib Impurity 149 (CAS CATO-C4X-1135149)
- N-(4-Chloro-2-fluorophenyl)-4-methoxybenzamide (CAS 546096-46-2)
- (2R,4R)-2-((1H-Indol-3-yl)methyl)-4-amino-2-hydroxypentanedioic acid (CAS 400769-81-5)
- Landiolol Impurity 17 (CAS CATO-C4X-262117)
- Ketoprofen Impurity N6 (CAS 1257296-76-6)
- [2-(Propan-2-yloxy)pyridin-3-yl]methanamine (CAS 851773-48-3)
- 1-(3-Fluorophenyl)-5-(pyridin-4-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1326882-69-2)
- Semaglutide Impurity 190 (CAS CATO-C4X-2226190)
Why CATO?
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